Endocrine Abstracts

Background: Sarcopenia is characterised by a loss of muscle mass and function and is negatively correlated with quality of life and clinical outcomes. It may be present despite a healthy or even high body mass index (BMI). Up to a quarter of NET patients are at risk of malnutrition, which may impact treatment outcomes and length of hospital stay. Research has shown that patients with pancreatic and intestinal NETs are at higher risk of weight loss than bronchial NETs. With an ...

Primary adrenal cysts are a relatively rare form of lesions with incidence of 0.06% in general population and higher prevalence in women (female-to-male ratio 2.3:1). Adrenal endothelial cysts are the most common form of adrenal cysts subtypes (45%) and they usually present with abdominal or flank pain, or nonspecific symptoms . Adrenocortical carcinomas are a rare condition as well, with an incidence of 1–2 per million per year. The typical clinical presentation may inc...

Introduction: One of the manifestations of Munchausen syndrome is the deliberate injection of insulin to achieve hypoglycemia or artificial hypoglycemia. If human insulin is injected, we will always determine high level of insulin and low level of Cpeptideatthemomentofhypoglycemia. Incasesof insulin analogues injection the diagnos is maybe difficult when we use analyzers specific only to human insulin: the low level of IRI and C peptide will be determined.<p class="abstext...

Introduction: One of the autoimmunenon-diabetic hypoglycemia (NDH) causes isthe antibodies to insulinreceptor (AB-rIRI) formation and/orinsulin resistance type B (TBIR).Objectives: To determine the prevalence of increased AB-rIRI level in patients with suspected NDH of different genesis and in healthy individuals; to determine significance of AB-rIRI investigation in NDH diagnosis.Methods: In a prospective study we determined AB-rI...

Background and aims: Diabetes (DM) is a huge global health emergency of the 21st century. Around 463 million adults haveDM. Every 2-nd adult with DM is undiagnosed. Over 374 million people have impaired glucose tolerance, their risk of developing DM is very high. According to Diabetes Atlas-2019 DM national prevalence for Georgia is 7.1%. Increasing prevalence of DM/other endocrine disorders, specific health needs ofthese populations, increasing load on healthca...

The ability of thyroid cell to accumulate iodine is due to presence of sodium iodide symporter (NIS). Differentiated thyroid cancer (DTC) maintain ability to express NIS and thus it makes possible to perform RAI treatment. In case of DTC cells loss the ability of NIS protein production and cell membrane embedding that leads to RAI treatment fail.The aim of our study was to find a relationship between the level of preoperatively defined NIS and recurrence...

Introduction: One of the autoimmune non–diabetic hypoglycemia (NDH) causes is the formation of antibodies to insulin (AB–IRI) or Hirata disease (HD).Objectives: To determine the prevalence of AB–IRI level increasing in patients with suspected NDH of various genesis and in healthy individuals.Methods: 96 patients aged 18–80 years with suspected NDH were included in prospective study. In all patients we determ...

Introduction: The description of a rare case of papillary thyroid cancer, neck paraganglioma, pituitary adenoma and Cowden-like syndrome.Case report: A 43-year-old woman presented with enlargement of her right thyroid lobe and a palpable ipsilateral neck mass. The pathology examination after operation of the two lesions revealed the synchronous presentation of a papillary thyroid carcinoma and a neck paraganglioma. Patient’s medical history included...

Introduction: Increased prevalence of thyroid autoimmunity has been described in few cases after successful treatment for Cushing’s syndrome. In De Quervain’s thyroiditis (DQT) autoimmunity does not seem to play a primary pathogenetic role.We describe two cases of DQT coinciding with the resolution of hypercortisolism, after successful treatment of Cushing’s syndrome/disease.Case 1: A 41-year-old female with Cushing&...

Introduction: VATER syndrome is a rare, usually sporadic, entity, including ≥2 of the following: vertebral defects (V), anal atresia (A), tracheoesophegeal fistula, esophageal atresia (TE) and radial or renal dysplasia (R).Maturity onset diabetes of youth (MODY) is a usually non-insulin-dependent type of monogenic diabetes mellitus (DM), usually in adults <25 years, with autosomal dominant inheritance, without the features of metabolic syndrome...