Endocrine Abstracts

Introduction: Animal studies suggest that maternal obesity may impact foetal brain structure and function and increase long-term susceptibility to neurodevelopmental and neuropsychiatric disorders. Few human studies have examined these associations with conflicting results. It is unclear if reported associations are due to genetic background or intrauterine mechanisms.Objective: To investigate the association of maternal and paternal obesity status with ...

Background: Glucose intolerance produces structural and functional changes in the arterial wall which contribute to the excess cardiovascular morbidity and mortality. The present study investigated association between glucose tolerance status and arterial stiffness in subjects with normal and impaired glucose regulation (IGR).Methods: The study group consisted of 283 Caucasian subjects, including 111 subjects with normal glucose tolerance (NGT), 61 subje...

Primary adrenal insufficiency could be a rare manifestation of antiphospholipid syndrome (APS) and may be a consequence of bilateral adrenal hemorrhage. Rosai–Dorfman disease (RDD) is sinus histiocytosis with massive lymphadenopathy, a rare histiocytic proliferative disorder with a distinctive microscopic appearance. The retro-peritoneum is an infrequent site of involvement as well as extranodal sites.We report a case of a 39-year-old female patient...

Distinguishing Cushing disease from pseudo-Cushing syndrome still remains a challenge, especially in some specific cases when absorption or compliance of dexamethasone used in diagnostical tests are questionable. Several versions of an intravenous (IV) test have been utilized and serve both in the initial and differential diagnosis of Cushing’s syndrome.We report a 59-year-old patient with macroadenoma of pituitary gland (revealed accidentally on MR...

Glucocorticoid receptor (GR) is a ligand-dependent nuclear receptor which regulates the transcription of a wide spectrum of genes that are responsible for vital immunological, metabolic, developmental, and anti-inflammatory functions. GR transcriptional regulatory effects are modulated by co-regulators including the tetratricopeptide 5 (TTC5) which has been shown to stabilize GR and alter its action in response to cellular stress. TTC5 is a stress-responsive activator of p300 ...

Glucocorticoid receptor (GR) is a hormone-dependent nuclear transcription factor that modulates the expression of genes involved in development, inflammation, and metabolism. In addition, as GR is a key factor in several steroid dependent cancers steroid hormones are extensively used in the treatment of cancers such as leukemia. The transcriptional activity of GR is cell type specific and its magnitude and target selectivity depend on multiple factors including posttranslation...

Background: Cross sectional studies in type 2 diabetic men have shown the 50% prevalence of hypogonadism. Testosterone deficiency worsens glycaemic control and accelerates the development of cardio-vascular disease. Therefore we investigated the effects of testosterone replacement therapy (TRT) on endothelial function in hypogonadal men with type 2 diabetes.Patients and methods: Thirty-three hypogonadal patients with type 2 diabetes, aged 35 years or old...

ObjectiveThe COVID-19 pandemic is an unseen international emergency causing major challenges in medical care delivery. Patients with some chronic endocrine disorders (obesity, type 2 diabetes, probably also hypertension, corticosteroid excess) have higher rates of acute COVID-19 complications and death. Due to the changes in outpatient management there is a clear danger of inadequate clinical support for endocrinology patients. The decision for face-to-f...

In late pregnancy the mother must mobilise considerable energy stores to support fetal growth. Failure to appropriately nourish the fetus has significant obstetric consequences – gestational diabetes and fetal growth restriction (FGR). Despite this, relatively little is known about how metabolic responses are stimulated in the mother, and how they may go wrong. We previously found that high levels of the product of an imprinted gene, Delta-like homologue-1 (D...

Study question: Does the combination of estradiol valerate (EV) and dienogest (DNG) have favorable effects on inflammation and lipids compared with ethinyl estradiol (EE) + DNG?What is known already: Use of combined oral contraceptives (COCs) increases HDL-cholesterol and triglycerides and promotes low-grade inflammation. The metabolic effects of COCs depend on both estrogen and progestin components. To our knowledge this is the first study comparing COC...