Endocrine Abstracts

Introduction: Nelson’s syndrome is a rare complication of Cushing’s disease treated with bilateral adrenalectomy. There is no effective medical treatment yet. Nelson’s patients respond to hypothalamic stimuli distinctly from patients with Cushing’s disease and those with Addison’s disease. We describe the responses to standard ACTH stimulation tests in a patient with Nelson’s syndrome.Case report: A 42-year-old woman present...

Introduction: In Russia, full-scale studies aimed at assessing the incidence of endocrine autoimmune diseases (eAID) in adult patients with vitiligo have not been conducted.Objectives: analysis of occurrence of eAID in patients with vitiligo.Methods: 1) The first part of the study included 39 patients aged 19-73 years with endocrine pathology and vitiligo, who were initially examined in Endocrinology Research Centre. 2)The second p...

Oxidative stress (OS) can have an impact both in the pathogenesis and in the progression of TC, as it has been shown to induce oncogenes and inhibit tumor suppressors. The main source of cellular ROS is represented by NADPH oxidases (NOXs). Aims of the study were to investigate the NOX-derived OS in TC samples, benign nodules and corresponding normal tissues, and to correlate the level of OS with histological classification, genetic profile and clinical and prognostic features...

Diabetes mellitus (DM) type MODY (Maturity Onset Diabetes of the Young) accounts 10% of cases of diabetes with onset before 35 years. The aim was to determine characteristics of the course of the main types of MODY.Materials and Methods: 45 patients aged 18 to 35 years diagnosed with MODY molecular genetic testing (next-generation sequencing technology and direct automated Sanger sequencing) were included: 31 had mutations in the GCK gene, 14 - ...

The age group under 45 years is the most difficult to determine the type of diabetes mellitus (DM), it can include type 1 (DM1), type 2 (DM2), MODY and LADA diabetes. Objective of the study: to determine clinical markers for differential diagnosis of types of DM in young patients.Materials and Methods: 202 patients with onset of diabetes aged 18 to 45 years were included: group 1 - 77 patients with MODY, 2 - 83 with DM 2, 3 - 14 with DM 1, 4 - 28 with LA...

The aim: To test cytotoxic effects of immune factors of patients with chronic diabetic foot ulcers on keratinocytes and fibroblasts in a 3D skin culture system.Materials and methods: In this study a multilayer 3D human skin model comprising of keratinocytes, fibroblasts and dendritic cells in an agarose-fibronectin gel was used. 20% serum of 13 patients with chronic noninfected diabetic foot ulcers, 13 diabetic type 2 patients and 13 healthy people and l...

Introduction: Familial hypocalciuric hypercalcemia (FHH) causes lifelong hypercalcemia, which, in general, is not associated with significant morbidity. FHH1, the most common type of the disease, is inherited in an autosomal dominant pattern and caused by inactivating mutations in the Calcium Sensing Receptor (CaSR) gene, located in chromosome 3. Inactivation of CaSR in parathyroid cells results in a shift of calcium set point to higher values with consequent...

Objective: The aim of the study was to assess the effectiveness and safety of long-term sibutramine therapy in routine clinical practice.Materials and methods: In total, 98 774 patients (82.3% women, 17.7% men), from 142 cities of the Russian Federation were enrolled in the PRIMAVERA program. The mean age of the patients was 39.39±10.38 years, the mean body weight was 99.1±14.28 kg, and the mean BMI was 35.7±4.41 kg/m2. Physicia...

Proper insulin injection technique is a prerequisite for achieving good diabetes control, reducing absorption variability, and getting the best effect from using the drug. At the same time, the rate of absorption of insulin depends on a number of technical features, which include the depth of needle insertion, the severity of blood flow and the presence of lipodystrophy in the injection zones. Compliance with a number of rules minimizes the variability of absorption of insulin...

Introduction: With the advent of modern imaging, up to 30% of adrenal pheochromocytomas are discovered incidentally in asymptomatic patients. Smaller tumors may be ‘pre-biochemical’ in their secretory capacity, but truly nonfunctioning tumors over 3 cm are exceedingly rare. We describe a case of a clinically and biochemically silent pheochromocytoma.Case report: A 65-year-old woman was found to have a left adrenal incidentaloma on an abdominal ...