Endocrine Abstracts

Case report: Potocki-Lupski Syndrome (PTLS) with obesityEiman Naghmuish1, Marisa Clemente1, Kamal Weerasinghe11Department of Paediatrics, Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, The UK.Introduction: Potocki-Lupski syndrome (PTLS) is a rare genetic disorder affecting 1:20.000 people worldwide, it is caused b...

Objective: To determine the effect of glycemic variability on cognitive function in patients with type 1 diabetes mellitus.Materials: Thirty patients with type 1 diabetes mellitus were examined at the age of 29.7 (27.45–30.4) years, the duration of the disease was 19 (15.1–20.3) years. Patients were divided into 2 groups: 1st group (n=15) – patients with cognitive impairment, 2nd group (n=15) – without.<p class="...

Introduction: The change in thyroid parameters is described in the case of antiepileptic treatment in the pediatric population, due to interferences within the hypothalamo-pituitary-thyroid axis and due to the increase in the rate of hepatic metabolism of thyroid hormones.Case presentation: We present the case of a 10-year-old boy who addressed our outpatient pediatric endocrinology department for endocrine evaluation in the context of weight growth abou...

Objective: To estimate psychological rehabilitation efficiency at adolescents with T1DM.Materials and methods: Total 58 adolescents with T1DM (30m, 28f), mean age (M±σ) 15.1±2.8 years (13.00–18.00), age of T1DM manifestation 5.1±3.9 years, were provided with the PedsQL4.0 questionnaire, scales of psychological well-being (SPWB). The rehabilitation program was developed: medical unit (lessons in diabetes school and doctor’s c...

There are limited numbers of studies concerning family education as a risk factor for obesity in children. We aimed to examine the relationship between a children’s weight and family/psychosocial factors, to establish gender differences in eating behavior in obese children.Materials and methods: This cross-sectional study involved 65 obese children (m/f=33/32, mean age 13.5±0.5 years) and 65 mothers. Obesity was defined as BMI scores at ...

Poor family functioning will be associated with inadequate parental monitoring and/or regulation of children’s eating and activity patterns. We aimed to examine the relationship between a child’s weight and a broad rang of family and maternal factors. Our hypothesis was that increasing adiposity in children would be associated with poor general family functioning, lower socioeconomic status, inappropriate parenting style. This cross-sectional study involved 56 obese ...

Introduction: Reactive hypoglycaemia (RH) is a complex problem, with no definite treatment apart from lifestyle changes.Methods: We used Sitagliptin in two patients with RH, who had tried lifestyle changes for at least 2 years but without much effect. A gentleman with initial BMI of 31.4 kg/m2 and another lady of BMI 24.1 kg/m2 was treated with Sitagliptin 100 and 50 mg daily, in view of their weight and thereby volume of distributi...

Osteoporosis is characterized by decreased bone mineral density (BMD) and deterioration of bone microarchitecture increasing fracture risk. The main goal of osteoporosis treatment is preventing osteoporotic fractures. The most important predictor of treatment mediated fracture risk reduction is the increase in BMD. Treatment of osteoporosis falls into three pharmacological classes: antiresorptive agents (SERMs, oestrogen, bisphosphonates (BP), denosumab), osteo-anabolic drugs ...

Hyperandrogenism is the main characteristic of PCOS therefore hyperandrogenism in women is best addressed when studying this highly prevalent syndrome. Besides the clinical features of oligomenorrhea, hirsutism and infertility, PCOS patients are often insulin resistant (IR), obese, they have arterial hypertension, dyslipidemia, an increased pro-thrombotic state, impaired glucose tolerance or frank type 2 diabetes (T2D). The prevalence of metabolic syndrome is doubled as compar...

Vitamin D is phylogenetically an old compound present in simple organisms without skeleton for millions of years. Its primary function, acting as a cytokine, has been the defence against microbial invaders. Vitamin D modulates the innate immune response by inducing the synthesis of endogenous antibiotics in monocytes-macrophages. Epithelial ‘barrier’ tissues in lung, gut, placenta and skin employ the same antimicrobial mechanisms. Vitamin D also interacts with dendri...