Endocrine Abstracts

Solvent and process variables were critical to optimize the extractions of potential hypoglycemic compounds within medicinal plants. Hence, the undertaken study was designed to evaluate the hypoglycemic effectiveness exhibited by extraction performed in decoction manner using water as solvent and compares it with an aqueous-methanol solvent extraction. To evaluate the extractions prepared, phytochemical assays and in vivo study in induced-diabetic rats were carried ou...

Introduction: Cryptorchidism is unilateral or bilateral absence of the testes from the scrotum. One of the differential diagnosis is congenital bilateral anorchia. Vanishing testes syndrome is associated with low serum AMH concentrations and an absent or subnormal response to stimulation with hCG. We report the case of a 22-year-old boy diagnosted with bilateral cryptorchidism and hypergonadotropic hypogonadism at the age of 17 years old. At the time of diagnosis the scrotum w...

Objectives: Pregnant women with type 1 diabetes (T1D) are associated with an increased risk of maternal fetal complications. Continuous subcutaneous insulin infusion [CSII] has been shown to improve metabolic control and perinatal morbidity. Few studies have compared the use of CSII with SAP (sensor augmented pump) therapy to flash glucose monitoring (FSL) in pregnant women with T1D. We aim to evaluate the possible differences between both monitoring systems associated with CS...

Background: Papillary thyroid carcinoma (PTC) is a well differentiated malignant tumour that usually has a good prognosis in vast majority of patients after thyroidectomy, suppressive hormonal, and radioiodine treatment. However 5–10% of PTC cases can develop local relapse and distant metastases.Purpose of study: To make a comparative morphological analysis of PTC in two groups of patients: i) with and ii) without local relapse (regional metastases)...

Introduction: Described in 1990 by N Sato et al., Takotsubo syndrome (TS) is an acute myocardial dysfunction with the development of heart failure.Objective: We present a description of the clinical case of ST after adrenalectomy for pheochromocytoma.Results: Pheochromocytoma of the left adrenal gland (methanephrine 553.7 pg/ml (norm <65) and plasma normmetanephrine 458 pg/ml (norm <196) was verified in 27-year-old...

Introduction: The primary incidence of T1DM in children in Belarus is 19.27‰. It’s noteworthy, modern training programs of Schools of Diabetes include questions of the psychological state.Objective: The study included 26 parents of children diagnosed with T1DM.Methods: we used questionnaire to assess the attitude of parents to child’s disease, HADS and social adaptation self-evaluation scales (T. Holmes, R. Ray).<...

Objectives: Orbital radiotherapy (OR) is the most commonly used second-line treatment for the severe forms of Graves’ orbitopathy (GO). The aim of our study was to assess the changes in the therapeutic response, ocular manifestations of GO and quality of life (QoL) during the first year after OR.Methods: The study involved 26 consecutive patients with active moderate-to-severe GO indicated for OR, 18 females, mean age 57&pm;12.5. At baseline all pat...

The purpose of this study is to assess the treatment outcome of pregnant patients with Graves-Basedow disease. In the period of 20 years 59 pregnancies in hyperthyroid patients were registered with Graves-Basedow disease in the Department of Nuclear Medicine in Clinical Hospital Bitola. Thyrostatic therapy was applied in 29 (56.5%) pregnant patients divided into 2 groups. The first group were patients who used methimazole therapy (MMT) or 50–400 mg propiltiuracil (PTU). O...

The cystic nodule is by its origin a real or pseudo cyst. According to the date of literature the papillary thyroid carcinoma is being detected in the cystic nodule in up to 27% of the cases. Ultrasound is the best diagnostic method of the cystic nodule and fine needle aspiration under ultrasound examination is a diagnostic method for cytological diagnosis.Results: Seventy patients with detected cystic nodule underwent fine needle aspiration and the aspi...

Introduction: Kallmann syndrome (KS) is a developmental disorder characterised by hypogonadotropic hypogonadism and anosmia. 30% of cases are related with genetic causes, with FGFR1 mutations being identified in 10%. There are more than 140 FGFR1 gene mutations identified. We present a female patient with KS due to a FGFR1 mutation, where the presenting features included primary amenorrhoea and anosmia.Case description: ...