Endocrine Abstracts

Introduction: Sweet’s syndrome is a rare, acute febrile neutrophilic dermatosis, associated with a variety of inflammatory and neoplastic conditions, drug reactions and rarely with a spectrum of thyroid dysfunction. A possible link between thyroid autoimmunity and Sweet’s syndrome has been previously suggested by rare reports of Hashimoto’s thyroiditis, subacute thyroiditis and classic Graves’ disease. We describe a case of ‘atypical’ hyperthyroid...

Introduction: Primary hyperparathyroidism (PHPT) may rarely coexist with non-medullary thyroid carcinoma (NMTC). We report the clinical manifestation and management of nine cases of synchronous PH and NMTC.Cases: Eight women and one man were included (mean age at diagnosis: 64±6.6 years). In all cases, PH was the initial diagnosis, whereas NMTC was detected incidentally, after ultrasound assessment for PH. The histological diagnosis of NMTC was clas...

Introduction: Bisphosphonates (BP) have been employed for many years and have demonstrated an excellent safety profile. Nevertheless, severe osteonecrosis of the jaw (ONJ) have been described in patients with bone metastases that were treated with BP for many years.Case: A 72 year old female with breast cancer and bone metastases treated with quadrantectomy, axillary lymph node dissection, radiotherapy, tamoxifen and pamidronate 90 mg/month. Two years la...

Introduction: Osteoporosis of pregnancy and postpartum is a rare clinical entity, which usually presents with back pain, due to spine fractures. We aimed to describe four different cases presenting with back pain and fractures post-partum, in who, with diverse underlying pathophysiology, recovery time and treatments used.Case 1: A 32-year-old patient presented with intense back pain and difficulty in standing and walking, 2 weeks after delivery. She had ...

Purpose: Estimation of the continuous glucose monitoring system (CGMS) in the value of diabetes mellitus type 1 (DM1) control.Materials and methods: 162 DM1 patients have been divided on 2 groups: 1st group with adequate control DM1 – glycated hemoglobin (HbA1C) ≤7.5% (n=38) and 2nd group with inadequate control – HbA1C>7.5% (n=124). All patients carried out CGMS with glycemia symmetrization scales and an estimation ...

Purpose: Estimation of the continuous glucose monitoring system (CGMS) in the value of diabetes mellitus type 1 (DM1) control.Materials and methods: 162 DM1 patients have been divided on 2 groups: 1st group with adequate control DM1 – glycated hemoglobin (HbA1C) ≤7.5% (n=38) and 2nd group with inadequate control – HbA1C>7.5% (n=124). All patients carried out CGMS with glycemia symmetrization scales and an estimation ...

Background and aims: Hypoglycemia can be a risk factor for adverse cardiovascular and cerebrovascular events. However, changes in platelets and coagulation hemostasis during hypoglycemia have not been extensively studied. The aim of this study was to assess the impact of insulin-induced hypoglycemia on the platelet activity, endothelial dysfunction and the physiological anticoagulant level in patients with DM1.Research design and methods: We studied seve...

Objective: Objective to study the hypolipidemic efficacy, hepatoprotective activity, and tolerance of the fixed-dose combination of essential phospholipids with methionine (EPL+M) - Eslidine in the combination therapy with A in patients (pts) with cardiovascular diseases (CVD) and type 2 DM who suffer from hyperlipidemia (HL) in order to optimize their treatment in daily clinical practice.Subjects and methods: The trial enrolled 60 pts (mean age 58.1&#17...

Introduction: Obesity and diabetes mellitus type 2 (T2DM) are considered as one of the major risk factor for coronary heart disease (CHD) development, but the mechanisms beyond this relationship still need to be clarified. miRNAs are supposed to be involved in regulatory mechanisms in this relationship.Aim: To determine miRNAs expression in patients with obesity and T2DM.Methods: MiRNAs were detected in peripheral blood of 43 patie...

Introduction: Obesity and type 2 diabetes mellitus (T2DM) are associated with cardiovascular diseases (CVD). Fibrotic changes in obesity include several molecular processes, including activation of Transforming growth factor β (TGF-β). Recent data indicate the involvement of Fibroblast growth factor 21 (FGF-21) as an important metabolic regulator, and even biomarker of metabolic changes in obesity and T2DM.Aim: To determine TGF-β and FGF-2...