Endocrine Abstracts

: White adipose tissue (WAT) has an important role in the regulation of metabolic homeostasis. It is well known that two distinct WAT depots in mammals, subcutaneous WAT (sWAT) and visceral WAT (vWAT) display different metabolic roles and it could be presumed that exert different response to various hormones. Numerous studies revealed leading role of insulin in both fat accumulation (lipogenesis) and adipocyte differentiation (adipogenesis) although it is not clear is there a ...

Objective: Vascular atherosclerotic changes, mediated by environmental and genetic factors, develop years before an event. Detection of vascular damage, using ultrasonographic measurement of carotid IMT, is predictive of future cardiovascular events. The present study was designed to investigate the impact of gestational weight gain (GWG) on early atherosclerotic changes during late pregnancy, using intima media thickness (IMT), as well as placental vascular circulation and in...

Introduction: Metformin is effective in reducing cardiovascular mortality, however may decrease vitamin B12 and folate levels, and increase levels of homocysteine. Hyperhomocysteinemia is associated with adverse impact on lipid parameters and renal function. The present study was designed to determine the effect of homocysteine lowering therapy by using group B vitamins and folate supplementations on lipid metabolism especially HDL cholesterol as well as kidney function assess...

Internal jugular vein thrombosis (IJVT) is generally related to central venous access devices (CVADs) because of endothelial trauma or inflammation. Other reported causes include neck surgery complication, malignancies, deep neck infections, intravenous drug abuse, ovarian hyperstimulation syndrome and hypercoagulable states.We report the case of a 47-year-old woman presenting with acute neck pain, local swelling and fever. Neck ultrasound with Doppler s...

Introduction: Recently there has been a steady increase in direct costs for treatment of patients with diabetic foot. Therefore, cost-effectiveness analysis of different treatment strategies of patients is important for healthcare organizations and is an additional argument when deciding on the allocation of financial resources.Aim: A comparative analysis of cost-effectiveness of non-specialized and specialized medical care for patients with diabetic foo...

Background: Ukraine does not yet have a national program for control of iodine deficiency and there are no recent data on the severity of the iodine deficiency disorders (IDD) in the country.Objective: The aim of the present study was to assess current IDD status in eastern Ukraine.Design: We conducted school-based 30-cluster survey in children 6-11-year-old in urban and rural areas. We measured urinary iodine concentration (UI) an...

Objective: Levothyroxine (LT4) is the gold standard of care for primary hypothyroidism. For most patients, it fully resolves the symptoms of hypothyroidism. However, a small proportion of treated individuals continue to experience symptoms even when euthyroid. The management of such patients has generated significant controversy and public attention throughout the years. This systematic review aims to analyse and evaluate the existing evidence for the benefits...

Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became ...

Introduction: A number of studies reported that almost every fifth patient with thalassemia hav e diabetes. Various factors could contribute to inadequate retrograde glycemic control in thalassemia patients co-existed with diabetes. According to published data, HbA1C seems to be an insufficient marker of the quality of diabetes control in thalassemia patients.Case report: We present a male 67 years old type 2 diabetes patient with disease history for 15 ...

Introduction: The effects of TSH and thyroid hormones on bone turnover are well-known. The aim of this study is to examine the influence of osteoporosis (Op) and cardiometabolic syndrome risk factors on bone mineral density (BMD) in the population of age-matched, normotensive and nondiabetic females.Material and methods: Cross-sectional study involved 76 females (average age 53±10 years), divided into three groups: hypo-, hyper-, and euthyroid. Pres...