Endocrine Abstracts

Introduction: To diagnose the hypoglycemic diseases (HD), firstly, proving the hypoglycemia presence is necessary. For this purpose, the prolonged fast test, which can reach 72 h, is performed. In case of late completion this test has a potential risk of hypoglycemic coma. Repeated glycemia control by glucometer brings discomfort to patients and increases the labor costs of medical workers. In this regard, it was relevant to conduct a study on the comparison of continuous gluc...

Introduction: Insulin autoimmune syndrome (IAS) is characterized by the development of hypoglycemia due to insulin and insulin autoantibodies (IAA) interaction. The disease has a strong association with certain alleles of HLA gene. In most cases the disease affects predisposed persons who take drugs containing the sulfhydryl groups. The IAA are also noticed in patients with other autoimmune pathology and in patients with multiple myeloma or monoclonal gammopathy. In c...

Objective: To evaluate the prognostic value of interleukin-8 studies in the development of thyrotoxic cardiomyopathy in patients with Graves’ disease.Materials and methods: 86 patients with newly diagnosed Graves’ disease were examined, aged 18 to 55 years (mean age 37 years [28; 45]) without previous cardiovascular events. All patients were analyzed by interleukin-8 by immuno-enzyme analysis. To determine the threshold value for Interleukin-8,...

Background: Obesity in pregnancy is associated with hyperinsulinemia, impaired endothelial function, inflammatory up-regulation and higher risk of placental pathological lesions. However not all obese individuals demonstrate similar metabolic profiles. The present study was designed to investigate placental histopathology in lesions that are associated with maternal and fetal circulation abnormalities, in nonobese and obese women with and without metabolic alterations.<p c...

Introduction: LADA exhibits characteristics of both type 1 diabetes mellitus (DM) and type 2 DM. Patients with LADA usually have some components of metabolic syndrome. GLP-1 agonists have been widely used in type 2 DM. GLP-1 agonist therapies have shown some promising glucose lowering effect in T1DM. Almost no information is available on glucagon and incretin secretion in patients with LADA as well as effects on glucose and C-peptide levels.Case report: ...

Background: Type 1 diabetesmellitus (T1DM) isthe most widespread metabolic/endocrine condition among children/adolescents in Georgia. T1DM patients aged 0–18 yrs are treated both in– and outpatiently. In 2015–2019 totally 533 patients were hospitalized, 211 of them had fresh T1DM. Special attention is paid to interactive diabetes education (IDE) of patients/their caregivers, thatis very important for adequate diabetes management. IDE is initiated from the day...

Pituitary macroadenomas usually present with symptoms due to a local mass effect or to hormone abnormalities. Acromegaly is due an excessive GH production, usually caused by a slow-growing pituitary adenoma. Acromegaly is an insidious disease. An average delay of 7 years is reported between the time of symptoms onset and diagnosis. According to main symptoms, acromegaly is usually diagnosed by internists, ophthalmologists or rheumatologists. It may be suspected by pneumologist...

Background: Headache often occurs as incapacitating symptom among the patients with acromegaly. GH involvement in the pathophysiologic mechanism and an analgesic effect of somatostatin analogues has been described, but the exact mechanism is not clear. Whether the pan somatostatine (sst)-receptor agonists are superior as concern the antinociceptive effect than the more selective ones is not evidenced.Case report: A 21-year old woman, diagnosed with acrom...

Aim: To define the frequency of diabetic retinopathy course in type1 diabetes mellitus (T1DM) patients with and depression; to study the relation between depression and diabetic retinopathy severity.Materials and methods: One hundred and thirty-three T1DM patients aged 40.27±12.17 years (56 males and 77 females) without exacerbation of chronic and acute inflammatory diseases and verified mental disorders were included into the study. The duration of...

Objective: Adiponectin is an adipocyte-derived collagen-like protein, highly specific to adipose tissue and may represent an important link between obesity and atherosclerosis. The present study was designed to investigate a possible association between serum adiponectin levels and early vascular changes in obese patients as determined by intima media thickness (IMT) and arterial pulse-wave contour analysis.Design: Obese subjects (n=47) were evalu...