Endocrine Abstracts

Neuroendocrine tumours (NETs) occur in multiple tissues and vary widely in clinical behaviour. Up to 70% of diagnosed patients have elevated circulating levels of chromogranin A, the only serum marker commonly used in clinical practice. However, its low sensitivity and the identification of confounding factors that compromise specificity have raised the need for additional or alternative markers for disease detection and management. Here we aimed to discover candidate NET mark...

Cellular reprogramming describes the process where a fully differentiated, specialized cell type is induced to transform into a different cell. Cell reprogramming techniques can become powerful tools for modelling diseases, drug testing and for personalized cellular therapy. The adrenal cortex is the primary site of steroid synthesis. Adrenal insufficiency, which can be life threatening, is caused by a number of adrenal disorders, and lifelong management of these patients with...

The rapidly increasing epidemic of obesity is one of the most challenging dilemmas facing endocrinologists all over the world today. The aim of our research was within the framework of the National Campaign ‘Early Detection and Prevention of Type 2 Diabetes Mellitus’ to evaluate the prevalence of obesity and overweight in the Belarusian population.Materials and methods: The Campaign involved opportunistic screening of individuals applying to th...

Some hematologic malignancies might increase the risk of fractures due to intrinsic factors of the disease but also because of the treatment with steroids or chemotherapy. The direct impact of novel targeted agents on the development of osteoporosis in these patients has not been recognized yet. A 64-years old female patient with B-cell chronic lymphocytic leukemia (B-CLL) has been followed for four years with no other comorbidities. In order to measure the burden of the disea...

Objectives: To determine the histopathological changes of the endometrium that occur during the period of perimenopause and postmenopause and to determine their association with the presence of obesity, diabetes, thyroid disorders and the levels of FSH, LH, estradiol, insulin and parathormone.Material and methods: This study involved 120 patients with fractionated explorative curettage due to abnormal uterine bleeding. The control group consisted of 40 h...

Objective: The aim of the study was to assess the impact of iodine supplementation (IS) on iodine intake, thyroid function and thyroid volume (Tvol) in pregnant women (PW) from iodine sufficient region of Zagreb, the capital of Croatia. The secondary aim was to asses the impact of nodular or diffuse thyroid ultrasound (US) pattern on serum thyroglobulin (Tg) measurement.Subjects and Methods: The study enrolled 91 PW taking IS (onIS) and 100 PW without IS...

Introduction: An undefined lesion detected by imaging methods in one or both adrenals is known as an incidentaloma. The size and capacity of the secretion are evaluated to determine its definitive management. It is extremely uncommon for a mixed adrenal incidentaloma to appear with elevated cortisol and medullar hormone output.Case report: A 21-year-old woman was admitted to the hospital with intermittent palpitations, headaches, and chest pain. She was ...

We present a female patient 56 years old, who was treated at the endocrinology department from the year 2006. The diagnosis of Addison’s disease was established and she was properly treated. At the same time primary hypothyroidism was diagnosed, also started treating it properly. She was regularly controlled more often at the first time, than yearly at outpatient clinic. In September 2015 she was in menopause. A few months before she noticed oedematous legs and arms and d...

Introduction: The isolated hyperparathyroidism (IHP) is a metabolism disorder characterized by an absent or low parathormon (PTH) and hypocalcemia. It can be acquired, autoimmune, a result of some syndrome and as a part of a family (FIHP). FIHP is an extremely rear disease which is inherited auto somatic dominant or auto somatic recessive as a result of a mutation of one or several different genes. Pathological calcifications in the cerebrum are a secondary form of calcificati...

Introduction: Pregnancy as a state of insulin resistance can predict diabetes development in some women, and is associated with increased risk for adverse outcome of neonate and for mother.Aim: The aim of this study is to analyse pregnancy outcome in relation to a disorder of glucose tolerance during pregnancy.Matherial and methods: The study included 77 healthy pregnant women in third trimester registered in Center for endocrinolo...