Endocrine Abstracts

Introduction: MEN4 syndrome is a recently described form of MEN in patients with parathyroid and anterior pituitary tumors, which may also develop bronchial, gastric and pancreatic neuroendocrine tumors. In general, the patients present with clinical signs of primary hyperparathyroidism and simptoms caused by pituitary hormones hypersecretion or due to the tumor mass. However, clinical cases with the coexistence of pituitary tumors and pheochromocytoma are very rare described....

Introduction: Thyroid cancer incidence has registered an important increase in the last years. Anaplastic thyroid cancer represent a rare malignancy with an aggressive biological behavior and a high mortality rate.Case presentation: We present the case of a 69-years-old woman who addressed our department for endocrine evaluation in the context of a right latero-cervical lymph nodes, complaining of mixed dysphagia and dyspnea, that developed progressively...

Hashimoto thyroiditis (HT) is the most common cause of hypothyroidism. Subacute thyroiditis (SAT) is an uncommon disease with characteristic clinical features. Co-existence of HT and SAT is very rare and diagnosis can be challenging.Case: A 42-year-old woman with HT and multinodular goitre under levothyroxine sodium (LT4) therapy admitted to internal medicine clinic with 1 month history of anterior neck pain radiating to jaw. Thyroid function ...

GH deficiency is clinically associated with non-alcoholic fatty liver disease. Here we describe a new in vivo model of pituitary GH modulation resulting in protection from hepatosteatosis, by over-expression of delta-like homologue 1 (Dlk1/Pref1) from endogenous control elements. This resulted in improved glucose tolerance with no primary defect in adipose tissue expansion, even under extreme metabolic stress. Rather, Dlk1 overexpression caused pitui...

IntroductionPituitary stalk interruption syndrome (PSIS) is a rare entity characterized by a triad of thin or interrupted pituitary stalk, aplasia or hypoplasia of the anterior pituitary and absent or ectopic posterior pituitary seen on magnetic resonance imaging (MRI). We are presenting the clinical case of a child who presented for short stature.Case presentationWe present the case of a 4 year and 8 months ...

Introduction: Besides medullary thyroid carcinoma and other endocrinopathies, people with MEN 2B have intestinal ganglioneuromatosis. A recent MEN2B cohort study reported high rates of gastrointestinal (GI) symptoms: we hypothesized these might have a major impact on patients’ daily lives.Methods: An online survey was conducted among patients from Association for Multiple Endocrine Neoplasia Disorders (AMEND). This incorporated relevant elements fro...

Diabetes mellitus (DM) is a metabolic disease, which is accompanied by systemic damage to organs, including the central nervous system. Clinically, these changes are associated with cognitive impairment, the pathogenesis of which is also largely heterogeneous.Objective: To evaluate the role of tau-protein in the diagnosis of cognitive impairment in patients with type 1 and type 2 diabetes.Materials and methods: The study was tested...

Background: Insulin resistance and dyslipidemia inobese subjectsare important for predicting future cardiovascular risk. Purpose of the study was to analyze the lipid profile of obese children depending on gender and insulin resistance status.Subjects and methods: 247 overweight and obese children (160 boys and 87 girls) aged 2 to 18 y.o. were examined in the pediatric endocrinology department. Lipids assessment included measurement of total cholest...

Purpose of the studyEvaluation of cerebral microcirculation using contrast and non-contrast magnetic resonance perfusion in patients with type 1 diabetes and cognitive dysfunction.Material and methodsThe study complied with generally accepted ethical rules. The study included 45 patients with type 1 diabetes mellitus with cognitive dysfunction and 20 patients without. All patients were continuously monitored ...

The oral antidiabetic drug, glibenclamide, stimulates the insulin producing β-cells constantly through a harsh mechanism which eventually may permanently reverse its endocrinofunction. The study investigates the protective effects from Swietenia seed and endocarp aqueous-methanol extract on pancreatic islets histology in rats of type 2 DM model. Phytochemical analyses were performed prior to the in vivo study to screen the aqueous-methanolic extract of the combin...