Endocrine Abstracts

Background: Delta-like homologue 1 (DLK1) encodes a transmembrane protein, which may also be secreted into the circulation. Levels are known to rise in maternal serum during late gestation and our genetic studies in the mouse have shown that this DLK1 arises from the conceptus. The cell population that secretes DLK1 into the maternal circulation has not been identified. In humans DLK1 has been shown to be differentially expressed in intrauterine growth restricted (IUGR) when c...

Introduction: Visceral obesity is a primary risk factor for metabolic syndrome and is associated with short- and long-term effects on physical and psychosocial health. It is now known that body mass index (BMI), which is used as the main method of diagnosing obesity, does not allow the assessment of body composition and differentiation of visceral adipose tissue.The aim of the study. To investigate the features of body composition that influence metabolic risks in primary scho...

Objective: To study the peculiarities of the composition in patients over 50 years old.Materials and Methods: The study involved 136 adults aged 50 to 82 years. All subjects underwent complex examination, which included anthropometry (height, weight, body mass index (BMI)) and body composition analysis using Inbody 770 (Inbody Co.Ltd., Korea). Statistical processing of the results was performed using MedCalc Statistic software.Results: women’s age w...

Actuality: At present, the role of chronic hyperglycemia in type 1 diabetes mellitus (DM1) in the onset of diabetic encephalopathy has been proven. At the same time, violations in the metabolic composition of brain cells were detected in persons with DM1, estimated with the proton magnetic resonance spectroscopy (1H-MRS). However, the relationship between the results of these studies has not yet been studied.The aim: To reveal the relationship...

Context: Several specific transcriptional factors, in view of their important role in thyroid organogenesis and thyroid specific gene expression, would be strong candidate genes for the etiology of TD. The homeobox transcription factor NKX2.5 was thought to be only required for the organogenesis of the heart tube. However, NKX2.5−/− embryos also exhibited a smaller outgrowing thyroid bud. Indeed, several loss ...

Introduction: Cushing’s syndrome (CS) results from inappropriate exposure to excessive glucocorticoids. Untreated, it has significant morbidity and mortality.Case report: A 38-year-old woman with a typical appearance of CS was admitted for further evaluation of hypercortisolism. The serum cortisol level was elevated without diurnal rhythm, with no adequate supression of cortisol after 1 mg dexamethasone suppresion test. Twenty-four-hour urinary free...

Objective: Hyperthyroidism is accompanied by low bone mass. Because the reference range of TSH levels is defined statistically, some individuals with high-normal TSH levels (TSH <10 mU/l), may have mild hypothyroidism (subclinical hypothyroidism) and reduced bone mass. We therefore determined whether serum TSH levels correlate with bone mineral density (BMD) in persons with subclinical hypothyroidism.Design: A cross-sectional study.<p class="abst...

Involutive hypoandria (late onset hypogonadism) is characterized by decline in serum testosterone and increase of gonadotropins. Changes of hypothalamo-pituitary-testicular axis sensitivity are influenced by primary testicular changes and altered neuroendocrine regulation during aging. To evaluate age-related changes in gonadotroph and Leydig cell sensitivity two groups were formed: 1) 35 men, 51.8±3.2 years old, BMI=28.2±3.1 kg/m2; 2) 32 men, 63.2±6....

Introduction: Obesity is often accompanied by comorbidites predisposing atherosclerosis. Carotid intima-media complex thickness (CIMT) is consisdered as a marker of initial asymptomatic atherosclerosis. The relationship of sex hormones to obesity and atherosclerosis has been extensively studied.Objective: The objective of the study was to analyze the correlation CIMT and sex steroid levels in severly obese pre-menopausal women.Meth...

Background and aims: Vitamin D deficiency during the perinatal period has been hypothesized to increase risk for several psychiatric disorders in humans. As newborn vitamin D levels are entirely dependent on maternal vitamin D status, vitamin D deficiency in utero may leave the infant vulnerable to cognitive defects and behavioral problems. Few human studies have examined these associations with inconclusive results. We aimed to investigate the associations of maternal 25-hydr...