Endocrine Abstracts

Background: Vitamin D is a vital hormone for calcium metabolism, bone and muscle health, and immune responses. Vitamin D deficiency affects entire Latvian population.Aim: To compare the effectiveness of different forms of vitamin D.Materials and methods: In a prospective, open-label, randomized study in the Jaunliepaja Primary Health Care Centre, data from 98 vitamin D deficient volunteers over one month at initiation of substituti...

Introduction: Some physiological changes in HbA1c during pregnancy should be considered to determine its optimal value for glycemic control. Erythrocytes half-life decreases during pregnancy, which is reflected in a decrease in HbA1c.Aim: The aim of this study is to analyse HbA1c during pregnancy in healthy population of pregnant woman. Matherial and methods: The study included 77 pregnant women in the first trimester registered in Center for endocrinolo...

Introduction: The basic characteristics of metabolism in pregnancy are changes from anabolic to catabolic conditions with an increase in insulin resistance, moderate, reversible increase in lipid concentration in the blood, and accumulation of fat stores in the mother’s tissues. Lipid metabolism is essential for the development of healthy pregnancy, and fatty acids are a significant source of energy and a key element for membrane synthesis, while cholesterol, in addition ...

Introduction: Grave’s disease is frequently associated with cytopenia. Pancytopenia, however, is rare. Thyroid hormones have a direct effect on myocardial contractility and left ventricle (LV) diastolic function. Only less than 1% of the patients with hyperthyroidism develop cardiomyopathy with impaired left ventricular systolic function.Case: A 51-year old woman was admitted to the Hospital of Lithuanian University of Health Sciences, Kaunas clinic...

Background: Individuals with gender incongruence receive gender affirming therapy which is fundamental to sex reassignment. Cross sex hormone treatment both improves and impairs several surrogate markers of cardiovascular risk. In the aging population of transsexual persons, we are called to address clinical endpoints of the long-term gender affirming hormone therapy.Aim: Aim was to assess changes in the fasting serum lipid profile during gender affirmin...

Incidentally discovered adrenal masses (incidentalomas) present challenges both in diagnosis and management. The bilateral adrenal mass carries a risk of hormone hypersecretion, but it could also present a metastasis from another primary carcinoma or be a part of genetic syndrome.We report a 68 year old patient with bilateral adrenal incidentalomas (revealed accidentally on US, confirmed by abdominal CT in 2015.) left 29 mm, right 33 mm in diameter, radi...

Objective: The aim of this study was to assess the relationships between the body composition elements in women with anorexia nervosa (AN).Description of methods: In this study women with AN and healthy women aged 19–33 years were investigated. Anthropometry for height, weight and body mass index (BMI) was performed. Body composition including lean mass, fat mass, fractional contribution of fat, bone mineral content (BMC), and bone mineral density (...

Introduction: The basic characteristics of metabolism in pregnancy are changes from anabolic to catabolic conditions. During early gestation, the fetus is dependent on maternal thyroid hormones that cross the placenta. Thyroid disease in pregnancy is a common clinical problem, at least 2–3% of women have thyroid dysfunction. Pre-conceptual education and appropriate diagnosis and treatment of thyroid dysfunction in early pregnancy are of great importance, with the aim of ...

Cofactors of the nuclear hormone receptors are crucial in regulating their transcriptional activity. The glucocorticoid receptor (GR) is a member of the nuclear hormone receptor superfamily, involved in the regulation of metabolism, inflammation and stress–responses and many GR cofactors are known, including p300. Here, we identify a new cofactor for GR: TTC5/Strap, tetratricopeptide repeat domain 5/ stress–responsive activator of p300. Strap is a TPR motif containin...

Introduction: Thyroid disease in pregnancy is a common clinical problem, at least 2–3% of women have thyroid dysfunction, and it is estimated that about 5–20% of women of reproductive age suffer from autoimmune thyroid disease. Subclinical thyroid disease during pregnancy may be associated with adverse outcomes. In the first trimester, the ‘normal’ range for TSH is reduced to 0.1–2.5 mIU/l, and in the second and third trimester is 3.0 mIU/l.<p clas...