Endocrine Abstracts

Introduction: The syndrome of apparent mineralocorticoid excess (AME), a genetic disorder, resembles findings similar to those in primary aldosteronism, but aldosterone levels are low. AME is due to deficiency in the 11-beta-hydroxysteroid-dehydrogenase-enzyme-type-2 isoform (11-beta-HSD2), which normally converts cortisol to cortisone to prevent its mineralocorticoid activity at the aldosterone-sensitive sites. The deficiency in 11-beta-HSD2 leads to marked elevation in net m...

Introduction: The aim of this study was to compare prolactin receptor gene (Prlr) expression in the duodenum, vertebra and kidney, during physiological and medicamentous hyperprolactinaemia.Methods: Wistar female rats 18 weeks old were divided into: Group P: nine rats, 3 week pregnant; Group M: ten rats that were intramuscular administrated Sulpirid (10 mg/kg) twice daily for 3 weeks; and age matched nulliparous rats as a control group: ten rats...

Background and aim: We carried out a prospective 1-year study to examine the association of sudomotor dysfunction with mortality in patients with chronic kidney disease.Materials and methods: 97 patients from dialysis unit (28 with diabetic nephropathy (DN); 37 with nephroangiosclerosis, (NA), 18 with glomerulonephritis (GN), 14 with other conditions (O)); 32 with type 2 DM and creatinine clearance (CrCl) 30–50 ml/min; and 24 transplanted patients w...

Glucocorticoid hormones are used in the treatment of variety of diseases, due to their diverse range of effects. Acute lymphoblastic leukaemia (ALL), the most common form of childhood cancer, is one such disease treated by glucocorticoids (GCs). Although there has been much success in the treatment of ALL with GCs, drug resistance remains a problem, despite the detailed knowledge of the signalling networks underlying the GC actions through the glucocorticoid receptor (GR). Sys...

Background: Thyroid storm is an extreme disorder that occurs in case of severe thyrotoxicosis. This is a life-threatening condition with mortality rates up to 10–20%. A typical dose of iodinated contrast media (ICM) contains approximately 13.500 µg of free iodide and 15 to 60 g of bound iodine, which represents an acute iodide load of 90 to several hundred thousand times the recommended daily intake of 150 µg. As a result of sudden exposure to high iodide loads...

Myxoid adrenocortical adenoma is a rare adenoma originated from adrenal cortex. A 51 years old male patient was admitted to our hospital due to hypertension and hypokalemia. He has a long history of nonregulated hypertension despite multiple antihypertensive medications. Hypokalemia was detected in last two years with potassium levels around 3.0 mmol/l on high supplementation dose up to 10–16 g of KCl/day. He is obese in the past 10 years. His family history was positive...

Background: Papillary thyroid carcinoma (PTC), the most common endocrine malignancy, is a tumor of indolent biological and clinical behaviour that usually has a good prognosis. Only a small percentage of patients are affected by aggressive variants of PTC: tall, columnar cell and diffuse sclerosing variants. These aggressive tumor subtypes are characterized by higher rate of local recurrence, regional and distant metastases than classic papillary PTC. Recently another clinical...

The plasma membrane thyroid hormone (TH) transporter, MCT8, is present in the human placenta from early gestation and is postulated to participate in transplacental transfer of TH. In vitro, MCT8 overexpression decreases the survival of human cytotrophoblast in a TH-independent manner.Objective: To examine the role of Mct8 in fetoplacental growth using the Mct8 knockout (ko) mouse model.Methods: Heterozygous females were mat...

Objectives: The selective estrogen receptor modulator, raloxifene, exerts a part of its actions through the estrogen receptor alpha activation. We explored if polymorphisms of ESR1 gene modify the effects of 6 months raloxifene treatment on endothelial function.Methods: Two intronic (PvuII and XbaI), and one exonic polymorphism (P325P) of ESR1 were analyzed in 53 postmenopausal women, mean age 59.7+6.2. The flow mediated endothelium ...

Objective: Limited data suggest that the rebound increase in bone resorption and rapid bone mineral density (BMD) decline following sudden interruption of denosumab therapy can be avoided in patients previously treated with bisphosphonates. We aimed to compare BMD changes in osteoporotic patients after denosumab discontinuation regarding their previous bisphosphonate (BP) therapy.Material and methods: There were 14 women (age 69 years, BMI 23.1 kg/m...