Endocrine Abstracts

Background: Diabetes mellitus is associated with abnormal autonomic function. Diabetes and impaired fasting glucose are associated with increased mortality, particularly from cardiovascular causes. Several factors, including fast heart rate, have been identified to be associated with an increased likelihood of having diabetes. Heart rate is a crude index of the autonomic nervous system tone, reflecting a balance of sympathetic and parasympathetic inputs, and correlates wi...

Introduction and objective: Platelets play an important role in the development of thrombotic events. Increase of mean platelet volume (MPV) may indicate pre-thrombotic conditions as a new cardiovascular marker. Larger platelets have been reported to be metabolically more active than smaller ones. Our aim of present study is to evaluate MPV levels in patients with papillary thyroid cancer.Materials and methods: Forty-seven patients with newly diagnosis m...

Introduction: Acromegaly is associated with skeletal changes that are characterized by appositional bone growth, increased bone dimensions and increased bone turnover. PTH is an important regulator of bone remodeling and its anabolic action requires the presence of GH. The strong correlation found between PTH concentrations and bone turnover markers in active and treated acromegaly has led to the suggestion, that the effect of GH on bone turnover may be mediated by PTH. Succes...

Objective: The current study aims to describe sexual desire in female-to-male transsexuals post SRS (sex reassignment surgery) using a validated questionnaire. The association between serum androgen levels and the intensity and frequency of sexual desire are examined. The data are compared to those of male-to-female transsexual persons.Design: Cross sectional study.Methods: Female-to-male transsexual persons, post SRS, (n=48...

Clinical Biochemistry is the science concerned with changes in the composition of blood and other body fluids, to aid the diagnosis of disease and monitor therapy. Clinical Scientists (Clinical Biochemists) and medical graduates (Chemical Pathologists) carry out complex and unusual analytical work and are responsible for the provision, appropriate use and development of the service. This can involve research to develop and implement new techniques, liaison with clinicians to a...

Transgender persons on gender-affirming hormonal therapy will have experienced a hormonal reversal that will have had direct and also indirect effects on bone, through body composition changes. Recent evidence suggests that transgender women, even before the start of any hormonal intervention, already have a lower bone mass including a higher frequency of osteoporosis, and a smaller bone size vs. cisgender men. During gender-affirming hormonal treatment, bone mass is maintaine...

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA). However, our findings suggest that the proportion of diabetics among patients undergoing non-traumatic, non-cancer related lower limb amputations has increased over the past decades despite comprehensive preoperative investigations and other surgical interventions. To further explore the underlying reasons for this, ...

The development of diabetes mellitus type 2 (T2DM) is affected by genetic and lifestyle factors. Polymorphisms within the KIR6.2 gene seem to be associated with a higher risk for T2DM. The protein encoded by this gene represents a potassium channel, which plays an essential role in insulin and glucagon secretion by the pancreas.A hyperglycaemic clamp without insulin was performed over 2 h in 10 healthy persons with the Kir6.2 E23K wild type Glu/Glu, 10 a...

Objective: To identify the prevalent fracture risk factors in the group of persons 50 years and older. Assess their impact on BMD in patients with a distal forearm fracture (DFF-fracture of the radius) over 50 years at low injury.Materials and methods: A comparative study among patients with DFF in the age group 50 years and older. Study based on medical records of city hospital traum depatment. Analised period 2009–2012. All patients underwent R-de...

Introduction: Quality of life in transsexual persons after transition is among the most important outcome factors.Methods: A specialist center cross-sectional study in 193 transsexual women and 128 transsexual men (mean age 42.5 years) after on average 7.4 years of cross-sex hormone therapy and 6.6 years since sex reassignment surgery (SRS), compared to an age-and gender matched control population (1 to 3 matching). Self-reported physical and mental heal...